web analytics
September 2, 2014 / 7 Elul, 5774
At a Glance
Sections
Sponsored Post
Jerusalem Mayor Nir Barkat (L) visits the JewishPress.com booth at The Event. And the Winners of the JewishPress.com Raffle Are…

Congratulations to all the winners of the JewishPress.com raffle at The Event



Broader Lessons from Genetic Studies of the Ashkenazi Jewish Population


While we know that exposure to pathogenic organisms can cause disease (e.g., stomach flu), little is known about whether there is a common core set of microbes (microbiome profile) that is shared between healthy people or individuals with the same disease. We already know that changes in diet, antibiotic treatment and various conditions, including obesity, may shift our normal bacterial balance. Small studies have shown a lower diversity of the gut microbiota found in Crohn’s disease patients compared to unaffected individuals, raising questions about the possible role of commensal bacteria in disease development. Moreover, the fact that the major genes found to be associated with Crohn’s disease are involved in the processing of microbial antigens and immune response further implicate commensal bacteria in the Crohn’s disease risk.

Despite preliminary data indicating substantial differences in gut microbial content between healthy individuals of different racial and ethnic backgrounds, no studies have compared a composition of the bacteria between Ashkenazim and non-Jewish Europeans. It should not be surprising if such differences exist, given the unique dietary and lifestyle traditions observed by Jews including kosher food and a mandatory hand-washing before meals (“netilat yadaim”) that could reduce exposure to infection. Therefore, under- or overrepresented microbiota in this population may help guide future efforts in developing novel treatments targeting commensal bacteria.

The use of isolated populations in genetic research has been demonstrated to be of special value by revealing how  small inter-individual differences in their human genome sequence increase the chances of detecting mutations that are disease-associated. Therefore, to help advance our understanding of complex diseases, the Ashkenazi Genomic Consortium was established. The “Ashkenome” is a new collaborative initiative seeking to identify how the unique genetic make-up of this population contributes to various conditions, including diabetes, Parkinson’s disease, schizophrenia, or aging. This information, along with microbiome data, can be used in future studies of more diverse populations and help lead to early diagnosis, a better means of prevention, and novel treatments for complex diseases such as Crohn’s.

Inga Peter is the Associate Professor in the Department of Genetic and Genomic Sciences at the Mount Sinai School of Medicine. Her research interest is to identify variations in the human genome that can explain susceptibility to common diseases such as obesity, diabetes, and Crohn’s disease that can lead to early prevention and personalized treatment of these conditions. She graduated from Tel Aviv University and completed her training at Tufts University in Boston. She lives in Westchester County, NY with her husband and 3 sons.

About the Author: Inga Peter is the Associate Professor in the Department of Genetic and Genomic Sciences at the Mount Sinai School of Medicine. Her research interest is to identify variations in the human genome that can explain susceptibility to common diseases such as obesity, diabetes, and Crohn’s disease that can lead to early prevention and personalized treatment of these conditions. She graduated from Tel Aviv University and completed her training at Tufts University in Boston. She lives in Westchester County, NY with her husband and 3 sons.


If you don't see your comment after publishing it, refresh the page.

Our comments section is intended for meaningful responses and debates in a civilized manner. We ask that you respect the fact that we are a religious Jewish website and avoid inappropriate language at all cost.

If you promote any foreign religions, gods or messiahs, lies about Israel, anti-Semitism, or advocate violence (except against terrorists), your permission to comment may be revoked.

No Responses to “Broader Lessons from Genetic Studies of the Ashkenazi Jewish Population”

Comments are closed.

SocialTwist Tell-a-Friend

Current Top Story
Candy-laden bulletin board greets children on their first day of school in the lobby of an Efrat apartment building. Sept. 1, 2014.
The message reads:
"To our dear children ... may it be a year of fun and happiness in your studies." 
Did You Know September 1 is an Israeli National Holiday?
Latest Sections Stories
LBJ-082914

What better proof do we need than the recent war with Hamas in Gaza, dubbed “Operation Protective Edge,” that transformed the pain and suffering of three families into a sense of unparalleled unity and outpouring of love of the entire nation of Israel?

Katzman-082914

So many families are mourning, and all along we mourned with them.

Astaire-082914

In addition to his great erudition, Rabi Akiva was known for his optimism.

Kupfer-082914-Chuppah

She told me that she was busy and that he could sit in his wet clothes for the rest of the day. It would teach him to be more careful.

What can we do to help him stop feeling so sad all the time?

Children with dyslexia or dysgraphia frequently have problems in social relationships.

Israel’s neighbors engaged in hostilities from the onset. The War of Independence was a hard-won battle. Aggression and enmity has followed for 66 years.

The contest will include student-created sculpture, computer graphic design, collage, videography, PowerPoint and painting.

David, an 8-year-old boy on the autism spectrum, recently attended a Friendship Circle event. As he entered he told his Dad, “I love coming to the FC programs ‘cause everyone loves each other.”

Goldsmith himself went on his own “voyage of discovery” to the places where his grandfather and uncle landed and were sent.

Frank proclaimed himself Zvi’s successor and the reincarnation of King David.

You’re probably wondering why the greatest advocate of fast and easy preps in the kitchen is talking about layer cakes, right?

Almost immediately the audience began singing and clapping and continued almost without stop throughout the rest of the concert.

As of late, vintage has definitely been in vogue in the Orthodox community.

More Articles from Dr. Inga Peters

This year marks the 80th anniversary of the influential paper published by a Mount Sinai physician, Dr. Burrill Crohn, and his colleagues that for the first time characterized a disease associated with severe inflammation of the intestine. Patients with what was later named Crohn’s disease develop diarrhea, fever, stomach pain, and often lose weight. Crohn’s is now classified as an autoimmune condition in which the immune system attacks its own healthy tissue in the gastrointestinal tract, causing chronic inflammation. It affects young individuals, and, even though it is not curable, it can be treated and controlled by medications and surgery.

Printed from: http://www.jewishpress.com/sections/health/broader-lessons-from-genetic-studies-of-the-ashkenazi-jewish-population/2012/08/12/

Scan this QR code to visit this page online: