Photo Credit: Courtesy Bar Ilan University
Prof. Yossi Mandel

Macular degeneration (AMD) causes blindness in millions of people in the Western world. It is the most common cause of severe vision loss in the Western world among those aged 50 and over, and its prevalence increases with age. Though there is no cure for AMD, significant recent advancements in artificial retina implants may lead to effective treatment.

Located inside the eye the retina contains light receptors (photoreceptors) which absorb light. Information is then processed and transmitted to the brain. The macula, the central area of the retina, processes most of the information that reaches the brain from the eye, enabling one to see while reading and driving, facial recognition, and any other activity that requires accurate vision. In the peripheral retina, the area of the retina outside the macula that assists mainly with spatial judgment, vision is 10-20 times less precise. In AMD precise vision is impaired due to damage to the center of the retina, while peripheral vision remains normal.

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When there is damage to the photoreceptor layers in the retina, an artificial retina — a device built from tiny electrodes smaller in width than a hair — may be implanted. Activating these electrodes results in electrical stimulation of the remaining retinal cells and results in visual restoration, albeit partially. AMD patients implanted with an artificial retina possess a combination of artificial central vision and normal peripheral vision. This combination of artificial and natural vision is important to study in order to understand how to help the blind. One of the critical questions in this regard is whether the brain can integrate artificial and natural vision properly.

In a new study published in the journal Current Biology (Cortical Interactions between Prosthetic and Natural Vision), researchers from Bar-Ilan University and Stanford University report for the first time the discovery of evidence indicating that the brain knows how to integrate natural and artificial vision, while maintaining processing information that is important for vision. “We used a unique projection system which stimulated either natural vision, artificial vision or a combination of natural and artificial vision, while simultaneously recording the cortical responses in rodents implanted with a subretinal implant,” said Tamar Arens-Arad, who conducted the experiments as part of her doctoral studies. The implant is composed of dozens of tiny solar cells and electrodes, developed by Prof. Daniel Palanker at Stanford University.

“These pioneering results have implications for better restoration of sight in AMD patients implanted with retinal prosthetic devices and support our hypothesis that prosthetic and natural vision can be integrated in the brain. The results could also have implications for future brain-machine interface applications where artificial and natural processes co-exist,” said Prof. Yossi Mandel, Head of Bar-Ilan University’s Ophthalmic Science and Engineering Lab and the study’s lead author.

The research was carried out in Prof. Mandel’s lab at the School of Optometry and Vision Science, Mina and Everard Goodman Faculty of Life Sciences and the Institute of Nanotechnology and Advanced Materials (BINA) at Bar-Ilan University’s, in collaboration with Prof. Palanker of Stanford University. The study was conducted by Tamar Arens-Arad in collaboration with Dr. Nairouz Farah, Rivkah Lender, Avital Moshkovitz and Thomas Flores.

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