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May 30, 2016 / 22 Iyar, 5776

Posts Tagged ‘Alzheimer’s disease’

Israeli Biotech Firm Starts Clinical Trials on Blood Test for Alzheimer’s

Monday, February 1st, 2016

An Israeli NeuroQuest biotech firm has launched clinical trials on its blood-based biomarker test to detect Alzheimer’s disease.

NeuroQuest announced last month they had entered into a service agreement with the University of California, San Diego for collection and processing of 700 blood samples for the U.S. clinical validation trials.

The South Carolina-based division of the biotech company is developing a blood test for early diagnosis of Alzheimer’s disease (AD).

Worldwide, nearly 47 million people have Alzheimer’s or a related dementia. In the United States alone, 5.3 million people are living with Alzheimer’s; it is estimated that figure will rise to 16 million by 2050 if a cure is not found.

The disease is usually diagnosed only after outward symptoms appear, and early diagnosis and treatment is extremely rare. No cost-effective, accurate and practical tools exist to diagnose the disease in the pre-clinical stage.

The test being developed by NeuroQuest for the at-risk population will serve as an inexpensive surrogate to costly PET (positron emission tomography) scans indicating the possible formation of brain plaques in the pre-clinical stage, according to officials at the Israeli biotech company, which is based in Misgav.

The blood test is based on close to 20 years of research led by Professor Michal Schwartz at Rehovot’s Weizmann Institute of Science, who also serves as president of the International Society of Neuroimmunology.

The NeuroQuest blood test was shown to be 87 percent accurate in human trials performed in Israel, with an 87 percent specificity rate in detecting ALS and Alzheimer’s.

Recent testing of the biomarker technology also exceeded the standards of the U.S. Alzheimer’s Association during a recent pilot study in Australia.

U.S. clinical trials are set to run from 2016 to 2017.

The firm’s U.S.-based research and development headquarters is located in Charleston, South Carolina. The company recently received a strong endorsement with the collaboration of the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging (AIBL).

NeuroQuest licensed the intellectual property covering the test technology from Yeda – the Weizmann Institute of Technology Transfer Arm – and holds an exclusive global license for its development and commercialization.

Hana Levi Julian

‘Dear Abby,’ Jewish Woman of Wisdom and Grace, Put Down her Pen

Friday, January 18th, 2013

Pauline Phillips, the daughter of Russian Jewish immigrants known to the world as the advice columnist behind “Dear Abby,” has died on Wednesday at age 94 after years of battling Alzheimer’s disease.

Born Pauline Esther Friedman in Iowa, Philips began writing the column in 1956 when she was 37 years old. Writing under the pseudonym Abigail van Buren, Phillips’ “Dear Abby” was syndicated in more than 1,200 newspapers and had 95 million readers at its height.

Phillips once wrote: “It is a sad commentary of our times when our young must seek advice and counsel from ‘Dear Abby’ instead of going to Mom and Dad.”

Her sister, Eppie Lederer, wrote a similar column under the name Ann Landers. Lederer died in 2002.

One of Pauline’s most famous quotes was: “It is true that I was born in Iowa, but I can’t speak for my twin sister.”

A few others revealed her feelings about religion:

“Religion, like water, may be free, but when they pipe it to you, you’ve got to help pay for piping. And the Piper!”

“A church is a hospital for sinners, not a museum for saints.”

And this very Jewish sounding quote, which could easily have sprung out of the Chapters of our Fathers::

“There are two kinds of people in the world. Those who walk into a room and say, ‘There you are’ and those who say, ‘Here I am.'” Pauline Phillips’ daughter Jeanne, the current woman behind “Dear Abby” published this note to both her mother’s and her own readers:

DEAR READERS: My beloved mother, Pauline Phillips, has passed away peacefully at the age of 94. Over the last quarter century Alzheimer’s disease had stolen away bit by bit her remarkable intellect, but she battled her illness with courage and dignity. She was my best friend who can never be replaced.

As those of you who have read this column when my mother wrote it know, Mama had a deeply caring heart, a lively sense of humor and a deep devotion to all of you. She tried every day to educate, enlighten and entertain, and to inspire civility and respect for others in the many thousands of people who sought her advice.

Her days in the office were spent answering letters and calling people who were in distress. Over the years, her list of sources, friends and contacts grew into a Rolodex that was legendary. The demands on her time and travel were many, but she was a loving mother, loyal wife, a caring friend and wonderful role model.

Mama was born on July 4, 1918, to Russian immigrant parents and was the youngest of four daughters. She often said that until she was 12 she thought all the fireworks were for her and her identical twin sister, Esther (Eppie).

She always had an interest in and deep concern for other people. After her marriage to my father, Morton Phillips, she put that interest into action and became president of her local mental health society and trained Gray Ladies for the American Red Cross. She honed her skills as a writer by writing a letter to her parents every day and to her sister-in-law who had contracted polio and spent a year in an iron lung.

Here are a few memorable quotes by Pauline Phillips’ “Dear Abby”:

If we could sell our experiences for what they cost us, we’d all be millionaires.

If you want children to keep their feet on the ground, put some responsibility on their shoulders.

The less you talk, the more you’re listened to.

If you don’t value what you have, you’re sure to lose it.

People who fight fire with fire usually end up with ashes.

Love is what enables us to bridge the gap of disappointment when others don’t live up to the expectations we have of them.

Because a jackass brays doesn’t mean you have to take it to heart.

Staying in a marriage without love is like serving a life sentence with an incompatible cell mate.

And, finally:

Loneliness is the ultimate poverty.

Yori Yanover

Printed from: http://www.jewishpress.com/news/breaking-news/dear-abby-jewish-woman-of-wisdom-and-grace-put-down-her-pen/2013/01/18/

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